Pathogenic infection confounds induction of the estrogenic biomarker vitellogenin in rainbow trout
Richard Burki
Centre for Fish and Wildlife Health, Vetsuisse Faculty, University of Bern, Bern, Switzerland
Search for more papers by this authorKathrin Bettge
Centre for Fish and Wildlife Health, Vetsuisse Faculty, University of Bern, Bern, Switzerland
Search for more papers by this authorCaird E. Rexroad III
National Center for Cool and Cold Water Aquaculture, U.S. Department of Agriculture–Agricultural Research Service, Kearneysville, West Virginia
Search for more papers by this authorSergej Afanasyev
Sechenov Institute of Evolutionary Physiology and Biochemistry, St. Petersburg, Russia
Search for more papers by this authorMia Antikainen
Institute of Applied Biotechnology, University of Kuopio, Kuopio, Finland
Search for more papers by this authorPatricia Burkhardt-Holm
Program Mensch Gesellschaft Umwelt, University of Basel, Basel, Switzerland
Search for more papers by this authorThomas Wahli
Centre for Fish and Wildlife Health, Vetsuisse Faculty, University of Bern, Bern, Switzerland
Search for more papers by this authorCorresponding Author
Helmut Segner
Centre for Fish and Wildlife Health, Vetsuisse Faculty, University of Bern, Bern, Switzerland
Centre for Fish and Wildlife Health, Vetsuisse Faculty, University of Bern, Bern, Switzerland.Search for more papers by this authorRichard Burki
Centre for Fish and Wildlife Health, Vetsuisse Faculty, University of Bern, Bern, Switzerland
Search for more papers by this authorKathrin Bettge
Centre for Fish and Wildlife Health, Vetsuisse Faculty, University of Bern, Bern, Switzerland
Search for more papers by this authorCaird E. Rexroad III
National Center for Cool and Cold Water Aquaculture, U.S. Department of Agriculture–Agricultural Research Service, Kearneysville, West Virginia
Search for more papers by this authorSergej Afanasyev
Sechenov Institute of Evolutionary Physiology and Biochemistry, St. Petersburg, Russia
Search for more papers by this authorMia Antikainen
Institute of Applied Biotechnology, University of Kuopio, Kuopio, Finland
Search for more papers by this authorPatricia Burkhardt-Holm
Program Mensch Gesellschaft Umwelt, University of Basel, Basel, Switzerland
Search for more papers by this authorThomas Wahli
Centre for Fish and Wildlife Health, Vetsuisse Faculty, University of Bern, Bern, Switzerland
Search for more papers by this authorCorresponding Author
Helmut Segner
Centre for Fish and Wildlife Health, Vetsuisse Faculty, University of Bern, Bern, Switzerland
Centre for Fish and Wildlife Health, Vetsuisse Faculty, University of Bern, Bern, Switzerland.Search for more papers by this authorAbstract
To examine the behavior of the estrogenic biomarker vitellogenin (VTG) under the combined impact of estrogens and pathogens, parasite-infected or noninfected rainbow trout were exposed to two doses of 17β-estradiol (E2). Infected and E2-exposed fish showed significantly lower hepatic VTG mRNA levels than healthy fish. Transcriptome data suggest that this was due to energetic constraints. Reduced responsiveness of the VTG biomarker in parasitized fish might obscure detection of low-level field exposure. Environ. Toxicol. Chem. 2012; 31: 2318–2323. © 2012 SETAC
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